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Clinical trial objectives The purpose of the clinical study in humans was to evaluate the efficacy of four weeks supplementation of a combination of vitamin B6, B9, B12, and taurine on motivated behavior, as a primary outcome, and on attentional performance, and self-reported mood (e.g., fatigue, vigor) as secondary outcomes

Further evidence from non-human primate models shows that intranasal administration of -syn preformed fibrils leads to iron deposition specifically within microglia, rather than DA neurons, in the substantia nigra

Ubiquitin Arg74 also forms a side-chain hydrogen bond with a conserved aspartate residue on ct UT3 12 (Asp194 of ct Ufd1, Asp191 of sc Ufd1, and Asp189 of hs Ufd1)

The case below is such an example