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The mechanism(s) of action underlying these changes is currently unclear, but results of preclinical work supports effects of ARA 290 on insulin resistance and muscle mitochondrial biogenesis (10) as well directly on insulin release (38)

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Since Gas6-deficient mice, challenged with cuprizone, display a potentiated demyelination and microglia activation, one may hypothesize that upon cuprizone treatment activation of microglia proceeds in a tightly controlled manner by expression of an arsenal of inhibitory molecules, such as CD200R, SIRP-, Gas6 receptors, and Trem2

AOD-9604 skips that problem entirely