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Kraljevic S, Stambrook PJ, Pavelic K

clinicaltrials.gov U.S

Side effects Metformin primarily causes GI side effects like gas, nausea, vomiting, diarrhea, indigestion, and stomach pain

NNMT is an enzyme that methylates nicotinamide, a key NAD+ precursor, depleting cellular methyl donor pools and influencing both NAD+ availability and broader methylation pathways