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DOI 10.1001/jama.2021.3224 - run-in nausea 47% falling to 14% at maintenance

The NHS advises that taking up to 2 mg (2000 micrograms) per day of vitamin B12 in supplements is unlikely to cause harm

Some people have lost a significant amount of weight, while others mention issues such as nausea or tiredness in the first few weeks

This alteration of the endothelium-mediated vasorelaxation is also observed in healthy subjects affected with moderate hyperhomocysteinemia (Tawakol et al, 1997