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Nephrotoxicity may occur due to expression of the drug target in kidney cells and is influenced by the role of the kidney in the metabolism and clearance of different drug classes (macromolecules versus small molecules) even when targeting the same receptor (Supplementary Table 2)

ISSN 2049-4637

[37] MET promoter has four putative binding sites for Ets, a family of transcription factors that control several invasive growth genes

BPC157 promotes cell proliferation and tube formation in endothelial cells Angiogenesis refers to the formation of new blood vessels from preexisting capillaries or postcapillary venules, a process critically dependent on the activation, proliferation, and migration of endothelial cells [14]