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Cellular and molecular mechanisms of curcumin in prevention and treatment of disease

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Compared with non-enzymatic reactions, the protein deamidation catalysed by enzymes is generally rapid and tightly regulated in response to various stimuli 54,55,56

That is the accurate description, and it is much weaker than clinically studied. There is also a mechanistic argument buried in Ionescu & Frohman that deserves attention: 90 mcg/kg produced no significant additional response over 60 mcg/kg [5]