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For negative mode acquisition, mobile phase A was 100% LC-MS grade H 2 O with 10 mM ammonium acetate, 0.1% ammonium hydroxide, and 0.1, 100% B

PGRN can be found in adipose tissue, epithelial tissue, gastrointestinal tract, reproductive organs, and so forth

Furthermore, the use of CRO has been shown to markedly decrease total tau protein levels and phosphorylation, suppresses - and -secretase activities, and reduces the deposition of A precursor protein (APP) accumulation in AD models by inhibiting ERK1/2 kinase activity (Rashedinia et al., 2015)