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The recent approach of regenerative medicine using mesenchymal stem cells (MSCs) could be advantageous for the treatment of ACLF as these cells can downregulate inflammatory response by inducing antiinflammatory events and prevent hepatic damage and fibrosis by inhibiting hepatic stellate cell activation and collagen synthesis

Donor organs are underutilized because of geographic limitations on donor-recipient matching and the restricted in vitro preservation duration

Another major barrier is the development of resistance mechanisms in patients, which are not always predictable from preclinical data (150)

Medical professionals are still unclear on the exact causes of fibromyalgia