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On the other hand, moderate hyperhomocysteinemia induces immune activation through ROS and oxidative stress (Schroecksnadel et al

Of note, while there are often 4 categories of severity for the measures evaluated in this study (i.e., minimal, mild, moderate, and severe), the minimal and mild groups were collapsed due to a small number of participants in each group

In an OGD/R-induced BV2 cell injury model, lobetyolin significantly inhibited the secretion of proinflammatory factors, such as TNF- and IL-6, downregulated the expression of inducible nitric oxide synthase (iNOS), and facilitated the M1-to-M2 phenotypic switch, thereby mitigating neuroinflammatory damage (Wang J

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