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who observed a close correlation between the ability of agonists to phosphorylate the S363 and the degree of DOR internalization (Bradbury et al., Concerning the rKOR, the phosphorylation-defective mutant S369E is unable to internalize upon U50,488 exposure demonstrating the role of receptor phosphorylation in endocytosis (Mclaughlin et al., 2003)

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