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Additionally, natural compounds [e.g., icariin II (234) and lycorine (241)] lack clear molecular targets: their direct binding partners or upstream signaling pathways (e.g., epigenetic regulators and kinase cascades) that modulate ferroptosis are poorly defined, hindering the optimization of potency and selectivity

These processes are closely regulated by complex interactions between hormones, nuclear receptors, and transcription factors, keeping hepatic lipid homeostasis under tight control [12]

(5) General paresis: psychiatric and behavioral disturbances such as increasing cognitive deficits, weakness of discrimination and judgment, psychotic episodes, speech disorders, abnormal pupillary reaction, epileptic seizures, reflex anomalies, dementia, and marasmus

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