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Description

Introduction Carnitine (3-hydroxy-4-N-trimethylammoniobutanoate) is an essential water-soluble molecule with multiple functions in the human body (6, 7)

This explains the long persistence of the H 2 O 2 molecule in the beta cell and maximizes the chance to be converted to the highly toxic HO at sites all over the beta cell, in particular when H 2 O 2 meets weakly complexed iron (II) ions (Halliwell and Gutteridge 2015

Vile et al., 2012

Furthermore, we employed a classical approach to estimate the false localization rate (FLR) of phosphosites using a DIA dataset acquired on 166 synthetic human phosphopeptides containing 176 clearly defined phosphosites 27