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4 Cardiovascular Diseases Aging and metabolic stress are associated with a decline in NAD+ levels, which can lead to mitochondrial dysfunction and increased susceptibility to cardiovascular diseases

Macroautophagy, the most prevalent autophagy form, initiates with the engulfment of cytoplasmic contents into a double-membrane structure called an autophagosome, which ultimately fuses with lysosomes to degrade its contents

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Further investigation into its underlying mechanisms revealed that CP ameliorates ALD by modulating GM diversity, reducing the relative abundance of Proteobacteria and Parasutterella while increasing that of Lactobacillus and Akkermansia, restoring intestinal barrier function, elevating the expression levels of intestinal tight-junction proteins, reducing the leakage of harmful substances such as LPS from the gut, and modulating the Nrf2/Kelch-like ECH-associated protein 1 pathway to diminish hepatic oxidative stress damage and inflammatory responses [227]