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[127] The main metabolic pathways involve aromatic para-hydroxylation, aliphatic alpha- and beta-hydroxylation, N-oxidation, N-dealkylation, and deamination

Managing missed doses appropriately is important for maintaining therapeutic benefits while avoiding adverse effects from irregular dosing patterns

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When investigating liver biopsies from a subset of the subjects ( n = 27), only cytoplasmic diacylglyceride levels, and not total or membrane-associated diacylglycerides, predicted hepatic insulin resistance [72]