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Description

Polymeric and small molecule-conjugates of temozolomide as improved therapeutic agents for glioblastoma multiforme

Keywords: NAD + , vitamin B3, nicotinamide riboside, niacin 1

The constructs CBS 516525 and CBS CD (residues 1413), along with single point mutations of CBS, were introduced using In-Fusion (Takara) or QuikChange (Agilent) mutagenesis and confirmed by sequencing