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TLRs are also involved in promoting functional DNA repair, repairing DNA damage caused by UVB radiation, and stimulating TLR2,3,4,7,8, and 9

Common side effects for topical corticosteroids include skin atrophy (thin and fragile skin with reduced elasticity), skin blood vessel changes (e.g., spider veins), change in skin color, stretch marks, swelling, dry skin, burning sensation, local irritation, rash, redness, itching, thinning hair or excessive hair growth, infections and allergic reactions

The result is a vicious cycle of worsening hormonal and metabolic symptoms and progression of the syndrome

Future multi-center clinical trials that incorporate various imaging modalities and stratify participants by various factors, such as age of onset and disease stage, will provide a more comprehensive understanding of FRDA and contribute to the development of new therapies