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Accumulation of parent drug and metabolites can occur with impaired renal function

Senile osteoporosis (elderly rat model) Experimental Design: Animal: 24 month old male Wistar rats (aged osteoporosis model)

[4] Administered parenterally, some clinical indications for the use of magnesium chloride include peritoneal dialysis, total parenteral nutrition (TPN), fluid and electrolyte replacement, and the management of cardiovascular diseases such as congestive heart failure, supraventricular tachycardia, ventricular arrhythmia, and atherosclerosis