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For example, elevated ROS were shown to inhibit EGFR and lectin receptor endocytosis in fibroblasts, likely by preventing their ubiquitination [90]

2022;9:e2200750

Hypoxia has been shown to promote the self-renewal capacity of GSCs as well as the ability to promote a more stem-like phenotype in the non-stem cell population by the up-regulation of important stem cell factors including Oct4 or Nanog (Heddleston et al., HIF-2 is likewise expressed in GSCs at oxygen levels comparable to normal in vivo levels (25%)

In comparison, the control compound troriluzole had a binding affinity of 6.0 kcal/mol, forming three HBs with Gln144, Ser227, and Cys229, as well as a carbon-HB with Thr231 and a pi-cation bond with Thr230 (Fig