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Garry Nolan for his support of the flow cytometry work represented in this manuscript

By the Bayesian framework, the estimated prevalence of PCD was 1:17,576 (95% confidence interval: 1:22,5511:14,001)

Moreover, SYP-14288-resistant mutant X19-7 significantly enhanced SYP-14288 metabolism on M1, and M1 accumulation in X19-7 might account for the decrease of the sensitivity to SYP-14288, whereas M2 and M3 were less important in the resistance

Oxidative stress occurs when there is an imbalance between the generation of free radicals (reactive oxygen species, ROS) and the bodys ability to neutralize them and fight them off