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Intranasal delivery, used with Selank and Semax, bypasses first-pass enzymatic metabolism in some systems, which partially explains why researchers observe longer effective durations than the IV values listed in typical half-life reference data

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At the AACR 2026, a poster presented by Crown Bioscience demonstrated how genOways hSA/hFcRn mice (genO-hSA/hFcRn), enable a predictive, humanrelevant PK assessment of ADCs across diverse linker and payload formats, showing how this model could be an alternative to replace the use of non-human primates (NHPs)

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