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This favors the reduction of glutathione, which is near equilibrium through the action of glutathione reductase (Krebs and Veech, 2 O 2 by the glutathione peroxidase reaction (Veech et al., 2001

When R-spondin 2 was added to explant cultures from wildtype mice, the number of outer hair cells decreased modestly, further indicating that R-spondin 2 has the opposite effect of -catenin activation in the developing cochlea and do not appear to potentiate canonical Wnt signaling to increase the number of hair cells (Jacques et al., 2014)

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