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doi: 10.1093/ajcn/88.3.855S 20 DingJ.ZhangY

Biochimica Biophysica Acta (BBA)-Reviews Cancer 1870 (2), 158164

First, TNF- is able to upregulate ACSL3, a key enzyme in the synthesis of acyl-CoA, which means TNF- promotes the lipid accumulation in cells, creating the conditions for the occurrence of inflammation response and ferroptosis [57]