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doi: 10.3390/ijms24010449 127 YamamotoMKenslerTWMotohashiH

In mouse models, increasing ovarian NAD + levels activates SIRT1 signaling, promotes mitochondrial biogenesis, improves energy metabolism, and enhances oocyte quality [303]

By modulating IGF-1 pathways, researchers aim to decipher how cellular maintenance and repair mechanisms function over time, providing insight into aging-related cellular phenomena