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While the functions of AHSG remain largely unknown, it is suspected to play an important role in blocking the transforming growth factor (TGF)-, which suppresses the activation and functions of NK cells [57,58,59]

A critical outcome of iron-driven lipid peroxidation is the activation of ferroptosis, a regulated, non-apoptotic form of cell death characterised by the accumulation of lipid hydroperoxides (80, 81) Ferroptosis is morphologically and biochemically distinct from apoptosis, necrosis, and autophagy, and is uniquely dependent on intracellular iron availability and oxidative lipid damage (8284)

Levels typically decline with age, chronic stress, and certain metabolic conditions, leading some people to seek supplemental forms

(2017) 6:S695