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Source numerical data and unprocessed blots are available in source data

Discuss your complete medical history , particularly: Personal or family history of thyroid cancer or Multiple Endocrine Neoplasia syndrome type 2 History of pancreatitis or severe gastrointestinal disease Kidney function status Other endocrine conditions, including diabetes complications Your doctor may coordinate care with specialists such as an endocrinologist, particularly if you have complex thyroid disease or difficult-to-control diabetes

To probe the structural transition in more detail, we assessed local nucleotide flexibility in the RNA using the SHAPE assay, which measures the relative nucleophilicity of the ribose 2-OH groups 68

Ou, Y.-N