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Fibroblast growth factors (FGFs), such as FGF21, show circadian expression and support vascular repair by enhancing VEGF signaling and promoting the activity of endothelial progenitor cells (EPCs) (86, 87).Together, these data suggest that therapeutic strategies targeting both clock components (CLOCK/BMAL1 or PER/CRY) and angiogenic factors (VEGFA/FGF) could enhance BBB recovery and improve outcomes after stroke

From this data, it appears that ATM augments x c antiport activity under basal conditions

75 Co-injection of A with another inducing agent, such as ibotenic acid, has been reported, 78,79 leading to significant neuronal death in the injection site and faraway regions, such as CA1, CA4, and the dentate gyrus compared to a single inducing approach

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