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doi: 10.1016/j.jad.2017.12.049 34 Samare-NajafMNeisyASamarehAMoghadamDJamaliNZareiRet al

alanine aminotransferase (increases from 14 to 4050 U/L)

A study in healthy non-human primates that received a high-protein meal followed by an oral dose of 370 mg/kg CDX-6512 treatment led to a statistically significant, dose-dependent reduction in plasma methionine levels, demonstrating the effectiveness of the enzyme in breaking down dietary methionine in a physiologically-similar model to humans (46)

To date, there are few dose-response studies on SFN that have been reported and the range of its effective doses is unclear