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E.ArdiniM.et al (2018)

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Mitochondrial dysfunction can drive senescence via reactive oxygen species (ROS) accumulation [68, 69], and Tat ( morphine) perturbs mitochondrial function, increasing ROS, protein oxidation, and cytokine release in microglia [60, 70]

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The mechanisms are well-characterized at the cellular level

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Supplementary Table S1 provides a condensed checklist designed for replication and peer-review clarity

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