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The aim was to gather research related to the etiology, inducements, pathogenesis, and treatment of migraines, with a particular focus on the roles of oxidative stress and inflammation in migraine and the therapeutic potential of topiramate therein

Fibrosis is initiated by the activation and differentiation of fibroblasts into myofibroblasts, triggered by transforming growth factor (TGF-) (Khalil et al., Reference Khalil, Kanisicak, Prasad, Correll, Fu, Schips, Vagnozzi, Liu, Huynh, Lee, Karch and Molkentin2017)

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Anesth Analg 93:12171221 Stupnisek M, Kokot A, Drmic D et al (2015) Pentadecapeptide BPC 157 reduces bleeding and thrombocytopenia after amputation in rats treated with heparin, warfarin, l-NAME and l-arginine