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We propose patients who pause treatment may have testing repeated after 2 weeks, while those with resolving aminotransferase elevations may reinitiate omaveloxolone with stepwise dose titrations and testing every 2 weeks for 3 months

This dysfunction often presents as increased oxidative stress, altered membrane potential and permeability, and mitochondrial DNA damage and mutations

Cellular stress defense MAMs function not only as structural platforms for metabolite exchange and signaling but also as key regulatory hubs during oxidative stress, calcium homeostasis disruption, or endoplasmic reticulum protein-folding stress

1 Introduction Spinal cord injury (SCI) is a highly destructive central nervous system trauma with a very high disability rate, which can lead to the loss of motor and sensory functions below the level of injury, as well as cause paraplegia or quadriplegia, putting patients in a predicament of lifelong disability (Mothe and Tator, 2012