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For example, inhibiting the key enzyme kynurenine 3-monooxygenase(KMO) promotes the metabolic flux toward the neuroprotective kynurenic acid(KYNA), which effectively alleviates neuropathic pain and its accompanying depressive-like behavior in preclinical models

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Iron overload induces ferroptosis by activating Piezo1, a pressure-sensitive calcium channel in chondrocytes, leading to subsequent calcium inflow, which could be exacerbated by conditional GPX4 knockout in cartilage

Effect of ascorbic acid, corticosteroids, and thiamine on organ injury in septic shock: the ACTS randomized clinical trial