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From a basic science standpoint, acetylcysteine neutralizes NAPQI in a 1:1 molar ratio, so the dose of acetylcysteine should be scaled up in proportion to the amount of acetaminophen

Further research has found that in intestinal epithelial cells with reduced or deficient GPx4, ACSL4 induces the release of interleukin 6 (IL6) and chemokine (C-X-C motif) ligand 1 (CXCL1) by regulating PUFA, especially Aa, leading to inflammation

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For example, TFEB-K91la impedes the ubiquitination and degradation of TFEB by weakening its interaction with the E3 ubiquitin ligase WWP2, ultimately leading to increased TFEB activity and autophagy flux in pancreatic cancer cells