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The consequences seem to be highly dependent on the degree of L-glu increase but even a 10% increase appears to affect nerve cell structure and survival particularly in the context of aging suggesting that chronic excitotoxicity may be particularly relevant to age-related neurodegenerative diseases

Dig Dis Sci 69 , 33443360 (2024)

Aerobic glycolysis increases levels of the abovementioned immune cells to varying degrees, which not only promotes the biosynthesis of these cells but also has important significance for controlling cell differentiation and regulating effectors (Donnelly and Finlay, 2015)

Although prospective or randomized designs provide stronger control over confounding factors, logistical constraints and ethical considerations limited their feasibility in this setting