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Description

It is a tetrameric protein with each subunit divided into four domains, the N-terminal threading arm, C-terminal helices, wrapping loop, and barrel [20] (Figure 4)

Zinc is an essential mineral that plays an important role in many biological functions

Raja SN, Carr DB, Cohen M, Finnerup NB, Flor H, Gibson S, et al

Barrier failure mechanisms arise from convergent cell death pathways: necrosis (with release of HMGB1 and ATP), NOX2-mediated apoptosis, NLRP3/gasdermin D-dependent pyroptosis, and ferroptosis driven by glutathione peroxidase 4 deficiency