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1 Supporting Data The approval for dato-DXd was supported by findings from 2 clinical trials: the Efficacy was evaluated in a pooled subgroup analysis of the TROPION-Lung05 and TROPION-Lung01 trials composed of 114 patients with locally advanced/metastatic EGFR -mutated NSCLC who had received prior EGFR-directed therapy and platinum-based chemotherapy

Metabolic Safety: IGF-1 and Glucose Effects One of the most clinically significant safety findings relates to AOD-9604s metabolic profile, particularly its lack of effects on insulin-like growth factor-1 (IGF-1) and glucose metabolism