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The accumulation of visceral adipose tissue tends to suppress adiponectin levels, resulting in insulin resistance, vascular dysfunction, and systemic inflammation

Inhibitors of Dimerization HIF-1 dimerization has been reported to be disrupted and its transcriptional activity inhibited by cyclic peptide inhibitor (cyclo-CLLFVY), which binds to the HIF-1 PAS-B region (Figure 5)