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As a result of the prevention of appetite loss, weight gain has been observed in WPC-administered MTX-treated rats

Acknowledgments Grant support for this research comes from Postdoctoral Fellowship Grant NCI 1F32CA247466-01 (A.V.- G.), NIDDK R33DK070291, NCI R01CA196643 (H.B.), NCI R37CA237421, R01CA248160, R01CA244931 (C.A.L), UMCCC Core Grant P30CA046592 (C.A.L), NCI P30 CA010815-53, NCI 5 R37 CA227865-04 (J.M.S.), American Cancer Society MRSG-14-019-01-CDD (J.M.W.), 134170-MBG-19-174-01-MBG (J.M.W.), NCI R37CA227865-01A1 (J.M.W.), the Case Comprehensive Cancer Center GI SPORE 5P50CA150964-08 (J.M.W.), Case Comprehensive Cancer Center P30 Core Grant P30CA043703 and University Hospitals research start-up package (J.M.W.)

The expression of the canonical L-lactate hydroxycarboxylic acid receptor 1 (HCA1) 625 is very low in the brain

Because this was a pre-post study without randomization or placebo control, the observed molecular shifts cannot be attributed unambiguously to L-serine