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Nausea represents the most frequently reported adverse reaction, affecting a significant proportion of patients, particularly during the initial weeks of therapy or following dose increases

& Liljegren, J

Typical findings may include: Low hemoglobin Low hematocrit Elevated mean corpuscular volume (MCV) Enlarged red blood cells General laboratory ranges often include: Serum folate below 2 ng/mL may indicate deficiency Serum vitamin B12 below 200 pg/mL may indicate deficiency Additional testing may be recommended when results fall into borderline ranges

The study included 155 controls (55 girls) and 15 patients each with episodic migraines (9 girls) and chronic migraines (10 girls)