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Gene essential analysis and in silico drug prediction In silico essential drug prediction was performed on all models using a modified version of the singleGeneDeletion function from the COBRA toolbox [28] and the biomass and ATP production as an objective function for cancer and control models, respectively

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As an opioid, hydrocodone bitartrate and acetaminophen tablets expose users to the risks of addiction, abuse, and misuse (see DRUG ABUSE AND DEPENDENCE)