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And we used to use a calcitonin, salmon calcitonin

The increased water solubility can be mediated also via conjugation reactions where glutathione serves as one of the substrates

Liu HH, Xu LQ, Yao K et al (2018a) Engineered 3-ketosteroid 9alpha-hydroxylases in Mycobacterium neoaurum : an efficient platform for production of steroid drugs