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Angioni D, Middleton L, Bateman R et al (2025) Challenges and opportunities for novel combination therapies in Alzheimers disease: a report from the EU/US CTAD Task Force

doi: 10.1101/pdb.prot087205 47 NunesCDepestelLMusLKellerKMDelhayeLLouwagieAet al

It has been identified that the length, start-site consensus sequence, secondary structures, upstream open reading frame, upstream the canonical AUG, internal ribosome entry site (IRES) and sequences that bind regulatory proteins present in 5UTR are responsible for the regulation of mRNA translation rate [52]

Intraocular pressure was measured in Indian subjects, and a small increase was noted but was not considered high and did not require pressure-lowering medication