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doi: 10.1016/J.FOCHX.2024.101118 85

Cortisol and the proteins that modulate its action, such as FKBP51 and FKBP52, directly influence the HPA axis and GR function

The STEP 1 trial, published in the New England Journal of Medicine , demonstrated that participants receiving semaglutide 2.4 mg weekly lost an average of 14.9 percent of their body weight over 68 weeks, compared to 2.4 percent with placebo (Wilding et al., 2021)