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In summary, being safe in patients with the inflammatory bowel disease, and devoid of toxic effects (LD1 could be not achieved, limit test negative) (21), gastric pentadecapeptide BPC 157 consistently counteracts analgesia in the mice placed on a hot plate and treated with morphine or morphine + haloperidol

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The reduction with BPC 157 is along with its previous reducing potential on severe superior sagittal sinus, portal, and caval hypertension and aortal hypotension (Vukojevic et al., 2018