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Additionally, -tocopherol enhanced antioxidant defenses by increasing SOD and GSH-Px activities, decreased pro-inflammatory cytokines such as IL-1, IL-6, and TNF-, and reduced neuronal apoptosis

Goiran T, Duplan E, Rouland L, El Manaa W, Lauritzen I, Dunys J, et al

Mutations in either nuclear or mitochondrial genomes causing mitochondrial dysfunction lead to a diverse group of disorders known as primary mitochondrial diseases (MDs), affecting predominantly high energy-requiring organs/tissues 2,3