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Isnt the statement .with no malice aforethought akin to saying I dont wish to be rude, but. Why make a point of such a statement when the irony is that the whole study is designed to cut down on perceived (and not scientifically backed up) excess treatment which served to harm patients and did not, by any stretch of the imagination prevent illness

Powers JH, et al: Sample size and ethics non-inferiority trials

If you are worried the shot will be painful you can rest assured that most clients find the discomfort negligible

In contrast, other studies reported an inverse relationship between Vit D and sleep quality [19, 20]