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Despite this low level of expression, reduced Tbx1 dosage in adult heterozygous mice leads to mild brain vessel hyperbranching and disorganization of the entire brain vessel network, as well as reduced brain vessel perfusion, and tissue hypoxia (38)

Selinexor inhibits XPO1 and has been approved for the treatment of patients with relapsed/refractory multiple myeloma after one to three prior lines of therapy in combination with bortezomib or pomalidomide with dexamethasone, or after 3 prior lines with dexamethasone alone