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Subpockets A and B are also mostly hydrophobic and with only a few polar groups available to make polar interactions with the ligand

Planta 198:365370 Kumar A, Bachhawat AK (2010) OXP1/YKL215c encodes an ATP-dependent 5-oxoprolinase in Saccharomyces cerevisiae: functional characterization, domain structure and identification of actin-like ATP-binding motifs in eukaryotic 5-oxoprolinases

Activation of PXR induces the expression of UGT1A1 the enzyme responsible for bilirubin glucuronidationas well as efflux transporters such as MRP2, enhancing bilirubin clearance from the liver

Ras-selective lethal small molecule 3 (RSL3) was originally thought to alter iron-related proteins and genes that caused the accumulation of polyunsaturated fatty acids and then caused cell death