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This, along with their beneficial effect on lipid levels, inflammation and glucose uptake, likely contributes to their beneficial cardiac effects

The Surviving Sepsis Campaign 2021 guidelines suggest starting AVP at a fixed infusion rate independent of weight (up to 0.03 IU/min) as an early adjunct when NE infusion rates reach 0.250.50 g/kg/min [10, 11], a threshold for AVP initiation that still needs to be validated [12, 13]

GLP-1RA might also be valuable in knee osteoarthritis (KOA) amelioration, which represents the typical load-bearing complication of obesity and a leading cause of disability and reduced health-related quality of life