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Mol Immunol 181:5365 Zhang Q et al (2024) Reducing Oxidative Stress-Mediated Alcoholic Liver Injury by Multiplexed RNAi of Cyp2e1, Cyp4a10, and Cyp4a14

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Relapse occurs in part due to the redox-induced dedifferentiation of non-GSCs that would add to this therapy resistance (Bao et al., Quite a few other mechanisms could be responsible, including OS, which would modulate the efficacy of treatments and resistance in various ways, impacting on drug sensitivity, apoptosis, angiogenesis, or inflammatory pathways (Nathan and Cunningham-Bussel, 2013)

The tradeoff is that the researcher must calculate two draw amounts and combine interpretation carefully