In addition, zinc plays a vital role in the thyroid hormones metabolism by regulating thyrotropin-releasing hormone (TRH) and TSH synthesis and modulating the structures of essential transcription factors involved in synthesizing thyroid hormones (177, 178)
Hesperidin, abundant in citrus fruits such as oranges and lemons, increases antioxidant defenses, inhibits neuroinflammation, and improves cognition ( Scutellaria baicalensis (Baikal skullcap), inhibits -synuclein aggregation, reduces oxidative stress, and has anti-inflammatory properties ( 5 Future perspectives of polyphenols in neuroinflammation and neurodegenerative treatment It is recommended that future investigations prioritize the elucidation of the precise molecular targets associated with polyphenols, the enhancement of their bioavailability, and the comprehension of their interactions with the gut-brain signaling pathway ( Recent research indicates that polyphenols have the ability to penetrate the blood-brain barrier, which is an essential characteristic for any substance that protects the brain ( 6 Potential limitations of polyphenols in neuroinflammation and neurodegeneration Polyphenols, while showing potential in the treatment of neuroinflammation, encounter limitations such as low bioavailability, instability in the gastrointestinal tract, and fast metabolism, which minimize their therapeutic effectiveness
Elkins, Kelly M
The distribution of amino acids relative to one another can also affect a protein's pI [31], and this is not taken into consideration with theoretical pI calculations
